IPT has a growing evidence base, particularly for depression, where it is one of the better-tested talking therapies and appears in treatment guidelines as a first-line option. Large meta-analyses have compared it with no treatment, with other psychotherapies, and with medication, and there is also a focused body of research on pregnancy and the first year after a birth. The picture is stronger for depression than for every other problem IPT has been tried with, and many trials still carry risk of bias, which is worth saying plainly. That is a strong foundation. It still is not a guarantee for any one person, and results vary with the problem you bring and the relationship you build in the room.
Cuijpers, P., et al. (2011), The American Journal of Psychiatry. A meta-analysis of 38 trials found IPT was associated with moderate improvements in depression compared with control conditions, performed similarly to other psychological therapies, and that combining IPT with medication in maintenance care was associated with lower relapse than medication alone.
Cuijpers, P., et al. (2016), The American Journal of Psychiatry. A comprehensive meta-analysis of 90 trials found IPT had moderate-to-large effects on acute depression compared with controls, may help prevent new depressive episodes, and showed promising effects for eating disorders and anxiety, while noting risk of bias in many studies.
Sockol, L. E. (2018), Journal of Affective Disorders. A systematic review and meta-analysis of IPT during pregnancy and the first year postpartum found it was associated with reductions in depressive symptoms in prevention and treatment studies, and with improvements in anxiety and relationship quality in the treatment studies.